Proper Dosage Guidelines for Tadalafil Pills

In studies, the most common daily pill side effects were headache, muscle pain, indigestion, and back pain. Men taking Cialis for daily use can experience a worrisome drop in blood pressure if they drink too much.

What should I do if I forget a dose?

Is tadalafil safe to take if I'm pregnant or breastfeeding?

Ask your doctor if any medications or supplements you take might interact with a daily erectile dysfunction pill, including blood pressure drugs, antifungal drugs, and HIV drugs. Also, men taking nitrate medications are advised not to take any ED drugs. While the manufacturer suggests that a 30-day supply of daily Cialis should cost about the same as eight pills of 36-hour Cialis a month, there's no way to enforce this. Check your insurance policy and local pharmacies for price information.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	5mg	180 + 10 Pills	159.65€ 152.05€	Buy
Cialis Generic	2.5mg	90 + 6 Pills	112.43€ 107.08€	Buy
Cialis Generic	40mg	20 Pills	59.47€ 56.64€	Buy
Cialis Generic	2.5mg	20 Pills	40.73€ 38.79€	Buy
Tadalista Super Active	20mg	90 + 10 Pills	314.14€ 299.18€	Buy
Tadalista Super Active	20mg	60 + 8 Pills	230.32€ 219.35€	Buy
Cialis Generic	2.5mg	60 + 4 Pills	83.43€ 79.46€	Buy
Cialis Generic	10mg	120 + 6 Pills	178.49€ 169.99€	Buy
Cialis Generic	10mg	30 + 4 Pills	63.32€ 60.30€	Buy
Cialis Generic	5mg	20 Pills	41.99€ 39.99€	Buy
Cialis Generic	40mg	120 + 8 Pills	206.98€ 197.12€	Buy
Cialis Generic	40mg	10 Pills	37.79€ 35.99€	Buy
Cialis Generic	20mg	10 Pills	31.49€ 29.99€	Buy
Cialis Generic	60mg	360 + 10 Pills	570.52€ 543.35€	Buy
Cialis Generic	60mg	270 + 10 Pills	443.96€ 422.82€	Buy
Cialis Generic	20mg	20 Pills	54.72€ 52.11€	Buy

– By Matthew Solan Executive Editor, Harvard Men's Health Watch As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.

Brand Name

In studies, the most common daily pill side effects were headache, muscle pain, indigestion, and back pain. Men taking Cialis for daily use can experience a worrisome drop in blood pressure if they drink too much. Ask your doctor if any medications or supplements you take might interact with a daily erectile dysfunction pill, including blood pressure drugs, antifungal drugs, and HIV drugs. Also, men taking nitrate medications are advised not to take any ED drugs. While the manufacturer suggests that a 30-day supply of daily Cialis should cost about the same as eight pills of 36-hour Cialis a month, there's no way to enforce this.

Why it’s used

Check your insurance policy and local pharmacies for price information. – By Matthew Solan Executive Editor, Harvard Men's Health Watch As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Get the latest in health news delivered to your inbox! No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Get the latest in health news delivered to your inbox! All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026.

Further information

Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability.

What should I tell my healthcare provider before using tadalafil?

atazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinibceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycinclarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed). Tadalafil is a clinically-proven erectile dysfunction treatment that gives you the freedom to enjoy sex when you want it. It lasts for 36 hours - so there’s less need for planning before sex. Find the clinically proven ED treatment that suits you best.

• Tadalafil enhances erectile response by increasing nitric oxide effects in the corpus cavernosum.
• It is approved by the FDA for the treatment of ED and BPH in men.
• The medication should be taken at least 30 minutes before sexual activity.
• Tadalafil's pharmacokinetics allow for flexible timing of doses.
• Patients with liver or kidney issues should consult their doctor before use.
• Combining tadalafil with other PDE5 inhibitors is not recommended.
• Tadalafil may cause vision changes, such as blurred vision or color tingling.
• Women should not use tadalafil, as safety has not been established for them.
• Tadalafil therapy may improve quality of life and sexual confidence.

No names, no logos, no delivery fee.

• Tadalafil comes in various tablet strengths, typically 2.5 mg, 5 mg, 10 mg, and 20 mg.
• It is not intended for use recreationally or by individuals without ED or BPH.
• Tadalafil can sometimes cause a sudden drop in blood pressure, so monitoring is advised.
• Patients should inform their doctor of all health conditions before starting tadalafil.
• Tadalafil may be used daily or as needed, depending on medical advice.
• Alcohol consumption can increase the risk of side effects when taking tadalafil.
• Overdose symptoms may include prolonged erection, chest pain, or dizziness.
• Tadalafil is available by prescription; do not buy it from unregulated sources.
• It is important to store tadalafil at room temperature, away from moisture.

4.6* from over 33,000 people like you. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Answer a few simple questions to get the treatment you need. Indicated for treatment of erectile dysfunction (ED) Cialis (or generic equivalent) or Chewtadzy only PRN use: 10 mg PO initially before sexual activity, with or without food; may be increased to 20 mg or reduced to 5 mg on basis of efficacy and tolerability; in most patients, maximum dosing frequency is once daily Once-daily use (Cialis): 2.5 mg/day PO in single daily dose, without regard to timing of sexual activity, with or without food; may be increased to 5 mg/day on basis of efficacy and tolerability Indicated for treatment of signs and symptoms of benign prostatic hyperplasia (BPH); daily use also indicated for treatment of patients with both BPH and erectile dysfunction Cialis (or generic equivalent) or Chewtadzy only BPH with ED: 5 mg PO once daily, taken at approximately same time each day without regard to timing of sexual activity Coadministration with finasteride for BPH: Tadalafil 5 mg plus finasteride 5 mg PO once daily for ≤26 weeks; incremental benefit of tadalafil decreases from 4 weeks until 26 weeks, and the benefit beyond 26 weeks is unknown Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, Tadliq, or generic equivalent only 40 mg PO once daily; dividing dose for more frequent dosing is not recommended Patients also taking ritonavir: 20 mg PO once daily initially for ≥1 week; may be increased to 40 mg/day on basis of tolerability Cialis, Chewtadzy (PRN use)Mild (CrCl >50 mL/min): No dosage adjustment neededModerate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hrSevere (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Mild (CrCl >50 mL/min): No dosage adjustment needed Moderate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hr Severe (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Cialis (once daily use)ED (CrCl >50 mL/min): No dosage adjustment neededBPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual responseED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended ED (CrCl >50 mL/min): No dosage adjustment needed BPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual response ED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended Chewtadzy (once daily use)BPH, ED/BPHCrCl >50 mL/min: No dosage adjustment neededCrCl ≤50 mL/min or hemodialysis: Not recommended CrCl >50 mL/min: No dosage adjustment needed CrCl ≤50 mL/min or hemodialysis: Not recommended Adcirca, Alyq, TadliqMild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerabilitySevere (CrCl <30 mL/min and on hemodialysis): Avoid use Mild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerability Severe (CrCl <30 mL/min and on hemodialysis): Avoid use Cialis, Chewtadzy (PRN use)Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once dailySevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once daily Severe (Child-Pugh class C): Not recommended Cialis, Chewtadzy (once daily use)Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advisedSevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advised Severe (Child-Pugh class C): Not recommended Adcirca, Alyq, TadliqMild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once dailySevere (Child-Pugh class C): Avoid use Mild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once daily Severe (Child-Pugh class C): Avoid use ED PRN use: Not to exceed 10 mg/72 hr ED or ED/BPH once-daily use: Not to exceed 2.5 mg/day Adcirca, Alyq, TadliqOn ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerabilityAvoid tadalafil during ritonavir initiationStop tadalafil at least 24 hr before to starting ritonavirAfter at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability On ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Stop tadalafil at least 24 hr before to starting ritonavir After at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Chewtadzy: Not indicated for once daily use for ED because dosing is not possible (recommended dosage for this indication cannot be achieved with lowest available strength) Orphan designation for Duchenne muscular dystrophy (DMD) Eli Lilly and Company; Lilly Corporate Center; Indianapolis, IN 46285 Indicated for treatment of erectile dysfunction (ED) Cialis or generic equivalent only: No dosage adjustment is warranted solely on basis of age; however, greater sensitivity to medications in some older individuals should be considered Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, or generic equivalent only: Lower dose or reduced dosing frequency may be required in elderly because of decreased renal or hepatic clearance Allow 48h after last tadalafil dose before nitrate administration.

• Tadalafil can also be used for pulmonary arterial hypertension under medical supervision.
• It's important to adhere to prescribed doses to prevent adverse effects.
• Tadalafil is less affected by eating fat compared to similar medications.
• The medication's onset is typically within 30 to 60 minutes.
• Tadalafil can be beneficial for men with both ED and BPH symptoms.
• It is possible to develop a dependence on tadalafil if used improperly.
• A healthcare provider may recommend periodic blood pressure monitoring.
• Tadalafil should not be taken with grapefruit juice; interactions may occur.
• Always complete the full course of treatment as prescribed by the doctor.

Allow 48h after last tadalafil dose before nitrate administration.

What About Other ED Medications?

nitroglycerin rectaltadalafil tadalafil in women increases effects of nitroglycerin rectal by additive vasodilation. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates.

Dosing & Uses

All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026. Tadalafil is a clinically-proven erectile dysfunction treatment that gives you the freedom to enjoy sex when you want it. It lasts for 36 hours - so there’s less need for planning before sex. Find the clinically proven ED treatment that suits you best. No names, no logos, no delivery fee.

When is 60 mg of tadalafil prescribed?

4.6* from over 33,000 people like you. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP Answer a few simple questions to get the treatment you need. Indicated for treatment of erectile dysfunction (ED) Cialis (or generic equivalent) or Chewtadzy only PRN use: 10 mg PO initially before sexual activity, with or without food; may be increased to 20 mg or reduced to 5 mg on basis of efficacy and tolerability; in most patients, maximum dosing frequency is once daily Once-daily use (Cialis): 2.5 mg/day PO in single daily dose, without regard to timing of sexual activity, with or without food; may be increased to 5 mg/day on basis of efficacy and tolerability Indicated for treatment of signs and symptoms of benign prostatic hyperplasia (BPH); daily use also indicated for treatment of patients with both BPH and erectile dysfunction Cialis (or generic equivalent) or Chewtadzy only BPH with ED: 5 mg PO once daily, taken at approximately same time each day without regard to timing of sexual activity Coadministration with finasteride for BPH: Tadalafil 5 mg plus finasteride 5 mg PO once daily for ≤26 weeks; incremental benefit of tadalafil decreases from 4 weeks until 26 weeks, and the benefit beyond 26 weeks is unknown Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, Tadliq, or generic equivalent only 40 mg PO once daily; dividing dose for more frequent dosing is not recommended Patients also taking ritonavir: 20 mg PO once daily initially for ≥1 week; may be increased to 40 mg/day on basis of tolerability Cialis, Chewtadzy (PRN use)Mild (CrCl >50 mL/min): No dosage adjustment neededModerate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hrSevere (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Mild (CrCl >50 mL/min): No dosage adjustment needed Moderate (CrCl 30-50 mL/min): Not to exceed 5 mg PO once daily initially; maximum dosage, 10 mg PO q48hr Severe (CrCl <30 mL/min and on hemodialysis): Not to exceed 5 mg PO q72hr Cialis (once daily use)ED (CrCl >50 mL/min): No dosage adjustment neededBPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual responseED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended ED (CrCl >50 mL/min): No dosage adjustment needed BPH or BPH/ED (CrCl 30-50 mL/min): 2.5 mg/day starting dose recommended; may increase to 5 mg according to individual response ED or BPH (CrCl <30 mL/min or hemodialysis): Not recommended Chewtadzy (once daily use)BPH, ED/BPHCrCl >50 mL/min: No dosage adjustment neededCrCl ≤50 mL/min or hemodialysis: Not recommended CrCl >50 mL/min: No dosage adjustment needed CrCl ≤50 mL/min or hemodialysis: Not recommended Adcirca, Alyq, TadliqMild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerabilitySevere (CrCl <30 mL/min and on hemodialysis): Avoid use Mild-to-moderate (CrCl 31-80 mL/min): 20 mg PO once daily initially; may be increased to 40 mg once daily on basis of tolerability Severe (CrCl <30 mL/min and on hemodialysis): Avoid use Cialis, Chewtadzy (PRN use)Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once dailySevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Not to exceed 10 mg PO once daily Severe (Child-Pugh class C): Not recommended Cialis, Chewtadzy (once daily use)Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advisedSevere (Child-Pugh class C): Not recommended Mild-to-moderate (Child-Pugh class A or B): Data limited; caution advised Severe (Child-Pugh class C): Not recommended Adcirca, Alyq, TadliqMild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once dailySevere (Child-Pugh class C): Avoid use Mild-to-moderate (Child-Pugh class A or B): Consider starting dosage of 20 mg PO once daily Severe (Child-Pugh class C): Avoid use ED PRN use: Not to exceed 10 mg/72 hr ED or ED/BPH once-daily use: Not to exceed 2.5 mg/day Adcirca, Alyq, TadliqOn ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerabilityAvoid tadalafil during ritonavir initiationStop tadalafil at least 24 hr before to starting ritonavirAfter at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability On ritonavir for at least 1 week: Start tadalafil at 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Stop tadalafil at least 24 hr before to starting ritonavir After at least 1 week following ritonavir initiation, resume tadalafil 20 mg PO qDay; may increase to 40 qDay based on individual tolerability Chewtadzy: Not indicated for once daily use for ED because dosing is not possible (recommended dosage for this indication cannot be achieved with lowest available strength) Orphan designation for Duchenne muscular dystrophy (DMD) Eli Lilly and Company; Lilly Corporate Center; Indianapolis, IN 46285 Indicated for treatment of erectile dysfunction (ED) Cialis or generic equivalent only: No dosage adjustment is warranted solely on basis of age; however, greater sensitivity to medications in some older individuals should be considered Indicated for pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability; studies establishing effectiveness included predominately patients with NYHA Functional Class II – III symptoms and etiologies of idiopathic or heritable PAH (61%) or PAH associated with connective tissue diseases (23%) Adcirca, Alyq, or generic equivalent only: Lower dose or reduced dosing frequency may be required in elderly because of decreased renal or hepatic clearance Allow 48h after last tadalafil dose before nitrate administration. Allow 48h after last tadalafil dose before nitrate administration. nitroglycerin rectaltadalafil tadalafil in women increases effects of nitroglycerin rectal by additive vasodilation. tadalafil increases effects of nitroglycerin rectal by additive vasodilation. Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer 24 hr before or within 48hr of each other. Either increases effects of the other by pharmacodynamic synergism.

Interaction / Contraindication	Description	Risk Level	Recommended Action
Nitrates	Can cause severe hypotension	High	Avoid use together
Alpha-blockers	Risk of blood pressure lowering	Moderate	Consult doctor for dosage
Grapefruit Juice	Affects drug metabolism	Moderate	Limit intake during therapy
Cardiovascular conditions	Risks vary depending on condition	Variable	Medical consultation required
Liver or Kidney Disease	May affect drug clearance	High	Medical advice necessary

Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. apalutamideapalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

• Tadalafil is not suitable for individuals taking certain antifungal or antibiotic medications.
• It may interact with blood thinning drugs, increasing bleeding risk.
• The common dosage and timing depend on individual health and condition severity.
• Tadalafil's shelf life is typically 2-3 years when stored properly.
• The medication is a prescription-only product in most countries.
• Patients should avoid using expired medication to prevent reduced efficacy or risks.
• Some health insurance plans may cover tadalafil depending on the diagnosis.
• Always check with a healthcare provider before combining tadalafil with other treatments.
• Tadalafil can help restore sexual confidence and improve intimacy quality.

Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible.

Dosage (mg)	Common Brand Names	Duration of Effect (hours)	Notes
10	Cialis	Up to 36	Suitable for daily use
20	Cialis	Up to 36	Most prescribed strength
5	Tadalafil Generic	Up to 36	Lower dose, for mild cases
25	Cialis Daily	Up to 36	For continuous activity
40	Not commonly used	Up to 36	Rarely prescribed

Evaluate for loss of therapeutic effect if medication must be coadministered.

What special precautions should I follow?

Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. tadalafil increases effects of nitroglycerin rectal by additive vasodilation. Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer 24 hr before or within 48hr of each other.

Tadalafil vs. sildenafil

Either increases effects of the other by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects. apalutamideapalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stop tadalafil >24 hours prior to protease inhibitor (PI) initiation, restart 7 days after PI initiation at 20 mg once daily, and increase to 40 mg once daily based on tolerability. atazanavir will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinibceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clarithromycinclarithromycin will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For ED limit tadalafil to max of 2.5 mg/day (for daily use) or 10 mg dose every 72 hr (for use as needed).

Before taking this medicine

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment: