Sildenafil cream demonstrates safety, efficacy in phase 2b study for female sexual arousal disorder

Addyi is a brand name for a nonhormonal medication called flibanserin.

What Would Viagra Do to a Woman?

Viagra may also cause increased blood flow to the genitals of people without a penis, which may help increase sensitivity, arousal, and orgasmic function. It helps to understand that sexual dysfunction is a complex issue. In a 2024 study, a topical cream with 3.6% sildenafil improved outcomes in people with female sexual arousal disorder (FSAD), particularly people without orgasm dysfunction. Another 2024 study found that age and hormonal contraceptives didn’t affect the effectiveness of topical sildenafil creams on FSAD. However, additional use of psychiatric medication decreased sexual desire in people using the cream and participants who used a placebo.

Mohamed Alhefnawy1*, Abdulla Esawy2, Mohamed Abdelazeem1, Mohamed Elnamoury3, Ahmed Eissa4, Ahmed Zoair4, Ahmed Ghaith4, Ayman Hagras4 and Khaled Almekaty4

More research is necessary to fully understand any potential benefit from the Viagra form of sildenafil for female sexual dysfunction. One thing buy sildenafil online uk that can suppress libido is the use of certain antidepressants, including: A 2025 review looks at the effects of various medications to treat antidepressant-induced female sexual dysfunction. It suggests that sildenafil may improve orgasm results and most Female Sexual Function Index scores. However, it had limited effects on pain during sexual activity. It was also not the most effective medication included in the review.

Regional issues

Viagra may cause blood pressure to drop. That can be a problem if you already have low blood pressure or take medications that lower blood pressure. Most information about Viagra’s safety looks at male use, not female use, particularly in the long term. More research is necessary to see if the same side effects may occur. The product label doesn’t include dosing information for FSAD because it’s not the intended use. You inject it under the skin on your abdomen or thigh about 45 minutes before you plan to have sex.

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Both medications are approved to treat acquired, generalized sexual desire disorder in premenopausal women. Specifically, it’s for low sexual desire that causes distress, but is unrelated to: Addyi and Vyleesi treat sexual desire, though the exact mechanism of action isn’t clear. They seem to affect certain pathways in the brain that influence sexual desire.

Where the Magic Happens

With increased blood flow to the penis, it’s easier to get and sustain an erection. Viagra targets sexual performance, not sexual arousal. There’s limited evidence that the drug is somewhat beneficial for female sexual dysfunction. This article explores whether viagra is safe or effective for female sexual dysfunction, and available alternatives. The use of binary terms such as “male” and “female” or “men” and “women” in this article reflects the language of the sources we’ve used.

Sexual Function after Spinal Cord Injury: Innervation, Assessment, and Treatment

Unless otherwise noted, it’s unclear whether the research we reference included participants with expansive gender identities. Yes, anyone can take sildenafil (Viagra), regardless of gender. Viagra is another brand of sildenafil that doctors primarily prescribe to treat erectile dysfunction. While the Food and Drug Administration (FDA) has not approved Viagra for female use, your doctor may prescribe it for off-label use. Like all drugs, Viagra can cause side effects.

Ospemifene (Osphena)

It can also interact with other medications. It’s important to speak with your doctor before taking Viagra. PDE5 is an enzyme that affects blood flow. Below are some potential effects of taking Viagra. Viagra dilates blood vessels and increases the flow of blood to the penis. Side effects of Addyi include low blood pressure, fainting, and nausea. These effects may be more intense if you take birth control pills or drink alcohol.

• Sildenafil is a medication primarily used to treat erectile dysfunction in men.
• Women sildenafil is an off-label use aimed at improving female sexual arousal.
• Clinical trials are ongoing to assess efficacy of sildenafil for women.
• Side effects of sildenafil may include headaches, flushing, and nasal congestion.
• Women may experience increased blood flow and libido with sildenafil.
• Proper dosage and medical consultation are essential before use.

Side effects of Vyleesi include a temporary increase in blood pressure and a decrease in heart rate. It can also cause nausea and isolated spots of skin lightening (focal hyperpigmentation). Viagra is FDA approved to treat erectile dysfunction.

• Some women seek sildenafil for increasing genital blood flow and sensation.
• The placebo effect can influence perceived benefits in women using sildenafil.
• Women with cardiovascular risk should avoid sildenafil unless approved by a doctor.
• Topical or alternative therapies might be considered alongside or instead of sildenafil.
• Scientific consensus on sildenafil’s safety for women remains under development.
• Proper dosing and medical oversight are key to minimizing risks.

It doesn’t have approval for treating female sexual dysfunction, and studies thus far have had mixed results.

Materials and Methods:

A doctor will decide on the dose and provide safety information. Viagra is an ED medication that improves blood flow to the penis. Viagra is a brand name, and there’s no “Viagra for women.” There are, however, a few FDA-approved medications to treat low female sexual desire. Because it’s a pink tablet and Viagra is a blue tablet, the nickname “female Viagra” was bound to happen. But these are different drugs with different missions. There’s no “female Viagra,” but there are a couple of drugs with approval to treat sexual dysfunction associated with specific conditions.

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In the intention-to-treat analysis, women receiving sildenafil had a statistically significant higher mean score improvement from baseline of 1.9 on the CGI than the 1.1 mean improved score for those receiving placebo. In the secondary outcome measures, sildenafil was associated with greater improvement on scores in the domain of orgasm function, including the ability to reach orgasm and to experience orgasm satisfaction. The investigators proclaimed this study important "not only because women experience major depressive disorder at nearly double the rate of men and because they experience greater resulting sexual dysfunction than men, but also because it establishes that selective phosphodiesterase type 5 inhibitors are effective in both sexes for this purpose." In later discussion, Nurnberg added, "the issue is keeping patients compliant with a medication by actively treating a side effect." Although acknowledging that clinical options include switching adversely affected patients from an SRI to an antidepressant having less incidence of sexual dysfunction, Nurnberg cautioned against discontinuing an effective agent with side effects and substituting another agent, which may or may not be as effective. Instead, he recommended that clinicians "encourage the patient not to stop the medication but to call to discuss which option would be useful-including waiting for it to go away." SildenÂafil treatment of women with antidepressant-asso-ciated sexual dysfunction: a randomized controlled trial. Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial.

A Note on Gender and Sex Terminology

Rudkin L, Taylor MJ, Hawton K. Strategies for managing sexual dysfunction induced by antidepressant medication. Sildenafil (Viagra) has Food and Drug Administration (FDA) approval for treating erectile dysfunction. It doesn’t currently have approval for female sexual dysfunction. Viagra can cause various side effects, including nausea, headache, and dizziness.

Study Design

It can also interact with other medications, so speak with a doctor before taking it. A doctor may prescribe viagra off-label if you have sexual dysfunction. Other medications, such as flibanserin (Addyi), may help treat female low sex drive. It’s an oral medication approved to treat erectile dysfunction (ED). The drug works by dilating blood vessels. There are many reasons for low sex drive.

Risk	Details	Precaution
Cardiovascular complications	Increased blood pressure, arrhythmias	Screen for cardiovascular disease before use
Drug interactions	Severe hypotension, adverse effects from combinations	Complete medication history before prescribing
Allergic reactions	Rashes, swelling, difficulty breathing	Discontinue and seek medical attention if occurs
Psychological dependency	Over-reliance on medication for arousal	Counseling for emotional health
Misuse and overdose	Increased adverse effects	Strict adherence to prescribed dose

Before taking Viagra or any other medication, talk with your doctor about the potential benefits, risks, and side effects of these medications for you.

Parameter	Description	Typical Values	Notes
Absorption Rate	Time to reach peak plasma levels	30-120 minutes	Varies with food intake
Half-Life	Duration of drug activity	4 hours	Metabolized mainly in liver
Bioavailability	Percentage of drug absorbed	40-50%	Affected by gastric pH
Metabolism	Enzymes involved	CYP3A4	Liver metabolism mainly
Excretion	How drug is eliminated	Feces and urine	Mainly fecal excretion

While some side effects such as nausea, dizziness, and headaches associated with selective serotonin reuptake inhibitor (SSRI) antidepressants tend to decrease or resolve over time, other side effects such as sexual dysfunction rarely remit spontaneously. Treatment of sexual side effects in women is especially important when about 30-70% of patients taking antidepressants may experience sexual side effects, combined with the fact that women are prescribed antidepressants at rates of 2 to 1 when compared to men. Sexual side effects in women may entail decreased sexual desire, difficulty with orgasm, genital sensitivity, reduced sexual activity, pain with sexual intercourse, decreased vaginal lubrication, and dissatisfaction or loss of pleasure from sexual activity. Sildenafil, marketed under the name Viagra, is a selective phosphodiesterase type 5 inhibitor approved for the treatment of erectile dysfunction in men, and has received study for men with depression and erectile dysfunction associated with SSRI treatment. In women, initial trials using selective phosphodiesterase inhibitors looking at both premenopausal and postmenopausal women did not show significant improvements for sexual arousal disorder; however, later randomized controlled trials supported their use for the improved frequency of sexual intercourse, arousal, orgasm, and satisfaction. conducted over 7 outpatient medical centers, 98 premenopausal women with remitted depression on SSRI antidepressants, ages 18-50 years old, were enrolled into an 8 week prospective, parallel- group, randomized, double blind, placebo controlled clinical trial. This study used the Clinical Global Impression sexual function scale as a primary measure, and also utilized the Female Sexual Function Questionnaire, the Arizona Sexual Experience Scale-female version, and the University of New Mexico Sexual Function Inventory- female version, a sexual activity event log, and the Hamilton Depression Rating Scale. This study showed that doses of sildenafil between 50mg-100mg, with the mean study dose of 91.7 mg, lead to an improvements in sexual side effects in the treatment group compared to the placebo control group. 28% of women taking sildenafil reported no improvement with the treatment, while 73% of women taking placebo reported no improvement. There was no statistical difference in the baseline and end-of-study Hamilton depression scores.

Rights and permissions

In studies, doses for female use may vary significantly. If you do plan on taking Viagra, consider the source. Some online sites that claim to sell Viagra are selling counterfeit drugs. These may not work like Viagra and may not be safe. To access the real thing, you’ll need a prescription. While there were no baseline endocrine value differences between the two groups, participants with higher levels of testosterone and thyroxin were more likely to experience improvement in sexual function, regardless of the assigned treatment group.